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The interior design has been modified to tidy margins, and art labeling has been simplified, so students can focus more clearly on the important concepts in a section. Beginning with Chapter 11, there are additional multi-step synthesis problems that rely on reactions learned in earlier chapters. The majority of these problems are written at the intermediate level-more advanced than the easier drill problems, but not as complex as the challenge problems. Over 350 new problems are included in the third edition. Twenty new NMR spectra have been added in Chapters 14–25 to give students additional practice in this important type of analysis. Some mechanisms have been modified by adding electron pairs to nucleophiles and leaving groups to more clearly point out the course of the chemical reaction. In addition, sections on splitting in NMR spectroscopy (Section 14.7) and substituent results in substituted benzenes (Part 18.6) have been rewritten to clarify and focus the material. In response to reviewer suggestions, new sections have been added on fragmentation patterns in mass spectrometry (Part 13.3) and peptide sequencing (Part 28.6). Janice Smith draws on her in depth educating background to deliver natural chemistry in approach during which college students learn: with limited use of text paragraphs, and thru concisely written bulleted lists and highly detailed, nicely-labeled “instructing” illustrations. This edition retains its popular delivery of natural chemistry content material in a student-friendly format. Organic Chemistry 4th Edition by Janice Smith continues to breathe new life into the organic chemistry world.